Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

被引：96

作者：

Beringue, Vincent ^{[1
]}

Herzog, Laetitia

Reine, Fabienne

Le Dur, Annick

Casalone, Cristina ^{[2
]}

Vilotte, Jean-Luc

Laude, Hubert

机构：

[1] INRA, UR892, F-78350 Jouy En Josas, France

[2] Ist Zooprofilatt Sperimentale Piemonte, Turin, Italy

来源：

EMERGING INFECTIOUS DISEASES | 2008年 / 14卷 / 12期

关键词：

D O I：

10.3201/eid1412.080941

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical ESE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.

引用

页码：1898 / 1901

页数：4

共 15 条

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