Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

被引:96
作者
Beringue, Vincent [1 ]
Herzog, Laetitia
Reine, Fabienne
Le Dur, Annick
Casalone, Cristina [2 ]
Vilotte, Jean-Luc
Laude, Hubert
机构
[1] INRA, UR892, F-78350 Jouy En Josas, France
[2] Ist Zooprofilatt Sperimentale Piemonte, Turin, Italy
关键词
D O I
10.3201/eid1412.080941
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical ESE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
引用
收藏
页码:1898 / 1901
页数:4
相关论文
共 15 条
[1]  
Baron T, 2007, EMERG INFECT DIS, V13, P1887, DOI 10.3201/eid1312.070635
[2]  
Baron TGM, 2006, EMERG INFECT DIS, V12, P1125
[3]   Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD [J].
Beringue, Vincent ;
Le Dur, Annick ;
Tixador, Philippe ;
Reine, Fabienne ;
Lepourry, Laurence ;
Perret-Liaudet, Armand ;
Haik, Stephane ;
Vilotte, Jean-Luc ;
Fontes, Michel ;
Laude, Hubert .
PLOS ONE, 2008, 3 (01)
[4]   Prion agent diversity and species barrier [J].
Beringue, Vincent ;
Vilotte, Jean-Luc ;
Laude, Hubert .
VETERINARY RESEARCH, 2008, 39 (04)
[5]   A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission [J].
Beringue, Vincent ;
Andreoletti, Olivier ;
Le Dur, Annick ;
Essalmani, Rachid ;
Vilotte, Jean-Luc ;
Lacroux, Caroline ;
Reine, Fabienne ;
Herzog, Laetitia ;
Biacabe, Anne-Gaelle ;
Baron, Thierry ;
Caramelli, Maria ;
Casalone, Cristina ;
Laude, Hubert .
JOURNAL OF NEUROSCIENCE, 2007, 27 (26) :6965-6971
[6]   Isolation from cattle of a prion strain distinct from that causing bovine spongiform encephalopathy [J].
Beringue, Vincent ;
Bencsik, Anna ;
Le Dur, Annick ;
Reine, Fabienne ;
Lai, Thanh Lan ;
Chenais, Nathalie ;
Tilly, Gaelle ;
Biacabe, Anne-Gaelle ;
Baron, Thierry ;
Vilotte, Jean-Luc ;
Laude, Hubert .
PLOS PATHOGENS, 2006, 2 (10) :956-963
[7]   Distinct molecular phenotypes in bovine prion diseases [J].
Biacabe, AG ;
Laplanche, JL ;
Ryder, S ;
Baron, T .
EMBO REPORTS, 2004, 5 (01) :110-114
[8]   Atypical bovine spongiform encephalopathies, France, 2001-2007 [J].
Biacabe, Anne-Gaaeile ;
Morignat, Eric ;
Win, Johann ;
Calavas, Didier ;
Baron, Thierry G. M. .
EMERGING INFECTIOUS DISEASES, 2008, 14 (02) :298-300
[9]   Atypical BSE in Germany - Proof of transmissibility and biochemical characterization [J].
Buschmann, A. ;
Gretzschel, A. ;
Biacabe, A. -G. ;
Schiebel, K. ;
Corona, C. ;
Hoffmann, C. ;
Eiden, M. ;
Baron, T. ;
Casalone, C. ;
Groschup, Martin H. .
VETERINARY MICROBIOLOGY, 2006, 117 (2-4) :103-116
[10]   Conversion of the BASE prion strain into the BSE strain: The origin of BSE? [J].
Capobianco, Raffaella ;
Casalone, Cristina ;
Suardi, Silvia ;
Mangieri, Michela ;
Miccolo, Claudia ;
Limido, Lucia ;
Catania, Marcella ;
Rossi, Giacomina ;
Di Fede, Giuseppe ;
Giaccone, Giorgio ;
Bruzzone, Maria Grazia ;
Minati, Ludovico ;
Corona, Cristiano ;
Acutis, Pierluigi ;
Gelmetti, Daniela ;
Lombardi, Guerino ;
Groschup, Martin H. ;
Buschmann, Anne ;
Zanusso, Gianluigi ;
Monaco, Salvatore ;
Caramelli, Maria ;
Tagliavini, Fabrizio .
PLOS PATHOGENS, 2007, 3 (03)