Neurofunctional correlates of attention rehabilitation in Parkinson's disease: an explorative study

被引:78
作者
Cerasa, Antonio [1 ]
Gioia, Maria Cecilia [1 ]
Salsone, Maria [1 ]
Donzuso, Giulia [1 ,2 ]
Chiriaco, Carmelina [1 ]
Realmuto, Sabrina [3 ]
Nicoletti, Alessandra [2 ]
Bellavia, Gabriele [3 ]
Banco, Aurelia [3 ]
D'amelio, Marco [3 ]
Zappia, Mario [2 ]
Quattrone, Aldo [1 ,4 ]
机构
[1] CNR, Ist Bioimmagini & Fisiol Mol, Unita Ric Neuroimmagini, I-88100 Catanzaro, Italy
[2] Univ Catania, Sez Neurosci, Dipartimento GF Ingrassia, Catania, Italy
[3] Univ Palermo, Dipartimento Biomed Sperimentale & Neurosci Clin, Palermo, Italy
[4] Magna Graecia Univ Catanzaro, Clin Neurol, I-88100 Catanzaro, Italy
关键词
Parkinson's disease; Cognitive rehabilitation; Attention deficits; Resting-state fMRI; Parieto-prefrontal cortex; COGNITIVE REHABILITATION; EXECUTIVE FUNCTIONS; MULTIPLE-SCLEROSIS;
D O I
10.1007/s10072-014-1666-z
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
The effectiveness of cognitive rehabilitation (CR) in Parkinson's disease (PD) is in its relative infancy, and nowadays there is insufficient information to support evidence-based clinical protocols. This study is aimed at testing a validated therapeutic strategy characterized by intensive computer-based attention-training program tailored to attention deficits. We further investigated the presence of synaptic plasticity by means of functional magnetic resonance imaging (fMRI). Using a randomized controlled study, we enrolled eight PD patients who underwent a CR program (Experimental group) and seven clinically/demographically-matched PD patients who underwent a placebo intervention (Control group). Brain activity was assessed using an 8-min resting state (RS) fMRI acquisition. Independent component analysis and statistical parametric mapping were used to assess the effect of CR on brain function. Significant effects were detected both at a phenotypic and at an intermediate phenotypic level. After CR, the Experimental group, in comparison with the Control group, showed a specific enhanced performance in cognitive performance as assessed by the SDMT and digit span forward. RS fMRI analysis for all networks revealed two significant groups (Experimental vs Control) x time (T0 vs T1) interaction effects on the analysis of the attention (superior parietal cortex) and central executive neural networks (dorsolateral prefrontal cortex). We demonstrated that intensive CR tailored for the impaired abilities impacts neural plasticity and improves some aspects of cognitive deficits of PD patients. The reported neurophysiological and behavioural effects corroborate the benefits of our therapeutic approach, which might have a reliable application in clinical management of cognitive deficits.
引用
收藏
页码:1173 / 1180
页数:8
相关论文
共 16 条
[1]
Computer-assisted rehabilitation of attention in patients with multiple sclerosis: results of a randomized, double-blind trial [J].
Amato, M. P. ;
Goretti, B. ;
Viterbo, R. G. ;
Portaccio, E. ;
Niccolai, C. ;
Hakiki, B. ;
Iaffaldano, P. ;
Trojano, M. .
MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (01) :91-98
[2]
Computer-Assisted Cognitive Rehabilitation of Attention Deficits for Multiple Sclerosis: A Randomized Trial With fMRI Correlates [J].
Cerasa, Antonio ;
Gioia, Maria Cecilia ;
Valentino, Paola ;
Nistico, Rita ;
Chiriaco, Carmelina ;
Pirritano, Domenico ;
Tomaiuolo, Francesco ;
Mangone, Graziella ;
Trotta, Maria ;
Talarico, Tiziana ;
Bilotti, Giacinta ;
Quattrone, Aldo .
NEUROREHABILITATION AND NEURAL REPAIR, 2013, 27 (04) :284-295
[3]
Evidence-Based Cognitive Rehabilitation: Updated Review of the Literature From 2003 Through 2008 [J].
Cicerone, Keith D. ;
Langenbahn, Donna M. ;
Braden, Cynthia ;
Malec, James F. ;
Kalmar, Kathleen ;
Fraas, Michael ;
Felicetti, Thomas ;
Laatsch, Linda ;
Harley, J. Preston ;
Bergquist, Thomas ;
Azulay, Joanne ;
Cantor, Joshua ;
Ashman, Teresa .
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2011, 92 (04) :519-530
[5]
The organization of intrinsic brain activity differs between genders: A resting-state fMRI study in a large cohort of young healthy subjects [J].
Filippi, Massimo ;
Valsasina, Paola ;
Misci, Paolo ;
Falini, Andrea ;
Comi, Giancarlo ;
Rocca, Maria A. .
HUMAN BRAIN MAPPING, 2013, 34 (06) :1330-1343
[6]
Anatomical and functional differences between the Paced Auditory Serial Addition Test and the Symbol Digit Modalities Test [J].
Forn, Cristina ;
Belenguer, Antonio ;
Belloch, Vicente ;
Sanjuan, Ana ;
Antonia Parcet, M. ;
Avila, Cesar .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2011, 33 (01) :42-50
[7]
ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].
HUGHES, AJ ;
DANIEL, SE ;
KILFORD, L ;
LEES, AJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184
[8]
The Parkinson's Disease Questionnaire (PDQ-39): development and validation of a Parkinson's disease summary index score [J].
Jenkinson, C ;
Fitzpatrick, R ;
Peto, V ;
Greenhall, R ;
Hyman, N .
AGE AND AGEING, 1997, 26 (05) :353-357
[9]
Executive functions in Parkinson's disease: Systematic review and meta-analysis [J].
Kudlicka, Aleksandra ;
Clare, Linda ;
Hindle, John V. .
MOVEMENT DISORDERS, 2011, 26 (13) :2305-2315
[10]
L-DOPA WITHDRAWAL IN PARKINSONS-DISEASE SELECTIVELY IMPAIRS COGNITIVE PERFORMANCE IN TESTS SENSITIVE TO FRONTAL-LOBE DYSFUNCTION [J].
LANGE, KW ;
ROBBINS, TW ;
MARSDEN, CD ;
JAMES, M ;
OWEN, AM ;
PAUL, GM .
PSYCHOPHARMACOLOGY, 1992, 107 (2-3) :394-404