Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones

被引：24

作者：

Koyama, J ^{[1
]}

Morita, I

Kobayashi, N

Osakai, T

Hotta, H

Takayasu, J

Nishino, H

Tokuda, H

机构：

[1] Kobe Pharmaceut Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6588558, Japan

[2] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 6028566, Japan

来源：

CANCER LETTERS | 2004年 / 212卷 / 01期

关键词：

Epstein-Barr virus; 2-azaanthraquinone; redox potential; cyclic voltammetry;

D O I：

10.1016/j.canlet.2004.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some 2-azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the 2-azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has been further shown that the correlation can be enhanced by introducing an electronic-properties, i.e. the atomic charges at the C-5 and O-12 atoms in the quinone skeleton ring and the HOMO energy as additional parameters. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

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