Supercritical-Fluid-Assisted One-Pot Synthesis of Biocompatible Core(γ-Fe2O3)/Shell(SiO2) Nanoparticles as High Relaxivity T2-Contrast Agents for Magnetic Resonance Imaging

被引：118

作者：

Taboada, Elena ^{[1
]}

Solanas, Raul ^{[1
,2
]}

Rodriguez, Elisenda ^{[3
,4
]}

Weissleder, Ralph ^{[3
,4
]}

Roig, Anna ^{[1
]}

机构：

[1] CSIC, ICMAB, Bellaterra 08193, Spain

[2] MATGAS 2000 AIE, Bellaterra 08193, Spain

[3] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02129 USA

[4] Harvard Univ, Sch Med, Boston, MA 02129 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2009年 / 19卷 / 14期

关键词：

SILICA PARTICLES; DELIVERY-SYSTEM; MRI; AEROGELS;

D O I：

10.1002/adfm.200801681

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monodisperse iron oxide/microporous silica core/shell composite nanoparticles, core(gamma-Fe2O3)/shell(SiO2), with a diameter of approximately 100 nm and a high magnetization are synthesized by combining sol-gel chemistry and supercritical fluid technology. This one-step processing method, which is easily scalable, allows quick fabrication of materials with controlled properties and in high yield. The particles have a specific magnetic moment (per kg of iron) comparable to that of the bulk maghemite and show superparamagnetic behavior at room temperature. The nanocomposites are proven to be useful as T-2 MRI imaging agent. They also have potential to be used in NMR proximity sensing, theranostic drug delivery, and bioseparation.

引用

页码：2319 / 2324

页数：6

共 34 条

[1] Silica particles:: A novel drug-delivery system [J].