Blood dendritic cells in patients with acute lymphoblastic leukaemia

被引：28

作者：

Ben Mami, N

Mohty, M

Chambost, H

Gaugler, B

Olive, D

机构：

[1] Univ Mediterranee, Lab Immunol Tumeurs, Inst Paoli Calmettes, F-13273 Marseille 09, France

[2] Inst Paoli Calmettes, Unite Transplantat & Therapie Cellulaire, Marseille, France

[3] Ctr Hosp Univ Marseille, Serv Pediat & Hematol Pediat, Hop Timone, Marseille, France

[4] INSERM, U119, F-13258 Marseille, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 126卷 / 01期

关键词：

acute lymphoblastic leukaemia; dendritic cell; haematopoiesis; interferon-alpha; immunotherapy;

D O I：

10.1111/j.1365-2141.2004.04989.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myeloid and plasmacytoid dendritic cells (MDCs, PDCs) play a key role in the initiation of immune responses. In this study, we show a severe reduction of MDCs and PDCs in patients with B lineage acute lymphoblastic leukaemia (B-ALL; P = 0.01 vs. controls). DCs from patients with T lineage ALL (T-ALL) were quantitatively and functionally comparable to healthy donors, as demonstrated by secretion of interleukin (IL)-12p70 and interferon-alpha. In vitro, the circulating CD34(+) fraction of B-ALL cases did not generate either CD1a(+) MDCs or PDCs, suggesting that DC development is probably affected in B-ALL, but not in T-ALL.

引用

页码：77 / 80

页数：4