Cancer immunotherapy with chemoattractant peptides

被引：20

作者：

Coscia, M

Biragyn, A

机构：

[1] NIA, Gerontol Res Ctr, Immunol Lab, Baltimore, MD 21224 USA

[2] Univ Turin, Azienda Osped San Giovanni Battista, CeRMS, Div Ematol,Lab Ematol Oncol, Turin, Italy

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 03期

关键词：

cancer immunotherapy; chemoattractant peptides; chemokine/chemokine receptor network;

D O I：

10.1016/j.semcancer.2003.10.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chemokine/chemokine receptor network is an essential part of an intricate system of immuno surveillance and homeostasis, it promotes or suppresses neovascularization, affects and regulates directly or indirectly growth and metastasis of malignant cells. Numerous studies have been conducted to harness this network as therapeutic agents for cancer to redress the chemokine balance and control angiogenesis and turnout growth and metastasis. Second generation of immunotherapeutics and chemoattractant-based vaccines use chemokines and chemoattractant peptides to elicit antitumor immunity by a specific targeting and modulating subsets of effector leukocytes, including professional antigen presenting cells. (C) 2003 Published by Elsevier Ltd.

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收藏

页码：209 / 218

页数：10

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