Synaptotagmin:: A Ca2+ sensor that triggers exocytosis?

被引：367

作者：

Chapman, ER ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 07期

关键词：

D O I：

10.1038/nrm855

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been fifty years since the discovery that Ca2+ triggers the rapid exocytosis of neurotransmitters from neurons. One of the proteins that has a crucial role in this secretion event is synaptotagmin I, an abundant constituent of synaptic vesicles that binds Ca2+ ions through two C2 domains. These properties prompted the idea that synaptotagmin I might function as a Ca2+-sensor that triggers neurotransmitter release. So does synaptotagmin trigger exocytosis in a Ca2+-dependent manner, and, if so, how does it operate?

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页码：498 / 508

页数：11

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