Modulation of indoleamine 2,3-dioxygenase by interferon-γ in human placental chorionic villi

被引：33

作者：

Kudo, Y

Boyd, CAR

Sargent, IL

Redman, CWG

机构：

[1] Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England

来源：

MOLECULAR HUMAN REPRODUCTION | 2000年 / 6卷 / 04期

关键词：

human placenta; indoleamine 2,3-dioxygenase; interferon; interleukin;

D O I：

10.1093/molehr/6.4.369

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of interferon-gamma on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi. The activity of indoleamine 2,3-dioxygenase was markedly stimulated by interferon-gamma in a time- and concentration-dependent manner. Interferon-alpha and interferon-beta also showed a slight stimulatory effect on indoleamine 2,3-dioxygenase activity. The level of indoleamine 2,3-dioxygenase mRNA expression (determined by reverse transcription-polymerase chain reaction) was also enhanced by interferon-gamma, Interleukin-4 showed a dose-dependent inhibitory effect on interferon-gamma-induced stimulation of indoleamine 2,3-dioxygenase activity and mRNA expression.

引用

页码：369 / 374

页数：6

共 29 条

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