The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology

被引：219

作者：

Nagy, I

Sántha, P

Jancsó, G

Urbán, L

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Dept Anaesthet & Intens Care, London SW10 9NH, England

[2] Univ Szeged, Dept Physiol, H-6720 Szeged, Hungary

[3] NIBRI, LDC, Preclin Compound Profiling, Cambridge, MA 01831 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 500卷 / 1-3期

基金：

匈牙利科学研究基金会;

关键词：

capsaicin; primary sensory neuron; brain; viscera; pain; inflammation;

D O I：

10.1016/j.ejphar.2004.07.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cloning of the vanilloid receptor 1 opened a floodgate for discoveries regarding the function of this complex molecule. It has been found that, in addition to heat, protons and vanilloids, this receptor also responds to various endogenous ligands. Furthermore, it has been also emerged that, through associations with other molecules, the vanilloid receptor 1 plays an important role in the integration of various stimuli and modulation of cellular excitability. Although, originally, the vanilloid receptor 1 was associated with nociceptive primary afferent fibres, it has been gradually revealed that it is broadly expressed in the brain, epidermis and visceral cells. The expression pattern of the vanilloid receptor 1 indicates that it could be involved in various physiological functions and in the pathomechanisms of diverse diseases. Here, we summarise the molecular, pharmacological and physiological characteristics, and putative functions, of the vanilloid receptor 1, and discuss the therapeutic potential of this molecule. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：351 / 369

页数：19

共 230 条

[11]

Aviado DM, 2001, ANN NY ACAD SCI, V940, P48

[12] Cooling inhibits capsaicin-induced currents in cultured rat dorsal root ganglion neurones [J].

Babes, A ;

Amuzescu, B ;

Krause, U ;

Scholz, A ;

Flonta, ML ;

Reid, G .

NEUROSCIENCE LETTERS, 2002, 317 (03) :131-134

[13] Type 1 vanilloid receptor expression by mammalian inner ear ganglion cells [J].

Balaban, CD ;

Zhou, JX ;

Li, HS .

HEARING RESEARCH, 2003, 175 (1-2) :165-170

[14] TREATMENT OF CHRONIC POSTHERPETIC NEURALGIA WITH TOPICAL CAPSAICIN - A PRELIMINARY-STUDY [J].

BERNSTEIN, JE ;

BICKERS, DR ;

DAHL, MV ;

ROSHAL, JY .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1987, 17 (01) :93-96

[15] Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury [J].

Bhatia, M ;

Saluja, AK ;

Hofbauer, B ;

Frossard, JL ;

Lee, HS ;

Castagliuolo, I ;

Wang, CC ;

Gerard, N ;

Pothoulakis, C ;

Steer, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4760-4765

[16] Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) [J].

Bhave, G ;

Hu, HJ ;

Glauner, KS ;

Zhu, WG ;

Wang, HB ;

Brasier, DJ ;

Oxford, GS ;

Gereau, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :12480-12485

[17] Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1 [J].

Birder, LA ;

Nakamura, Y ;

Kiss, S ;

Nealen, ML ;

Barrick, S ;

Kanai, AJ ;

Wang, E ;

Ruiz, G ;

de Groat, WC ;

Apodaca, G ;

Watkins, S ;

Caterina, MJ .

NATURE NEUROSCIENCE, 2002, 5 (09) :856-860

[18] Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells [J].

Birder, LA ;

Kanai, AJ ;

de Groat, WC ;

Kiss, S ;

Nealen, ML ;

Burke, NE ;

Dineley, KE ;

Watkins, S ;

Reynolds, IJ ;

Caterina, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (23) :13396-13401

[19] Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor [J].

Bonnington, JK ;

McNaughton, PA .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 551 (02) :433-446

[20] Bidirectional control of airway responsiveness by endogenous cannabinoids [J].

Calignano, A ;

Kátona, I ;

Désarnaud, F ;

Giuffrida, A ;

La Rana, G ;

Mackie, K ;

Freund, TF ;

Piomelli, D .

NATURE, 2000, 408 (6808) :96-101

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