Histopathological findings of new in-stent lesions developed beyond five years

被引:59
作者
Hasegawa, Katsuyuki
Tamai, Hideo
Kyo, Eisho
Kosuga, Kunihiko
Ikeguchi, Shigeru
Hata, Tatsuhiko
Okada, Masaharu
Fujita, Shinya
Tsuji, Takafumi
Takeda, Shinsaku
Fukuhara, Rei
Kikuta, Yuetsu
Motohara, Seiichiro
Ono, Kazuo
Takeuchi, Eiji
机构
[1] Shiga Med Ctr Adults, Dept Cardiol, Shiga 5248524, Japan
[2] Shiga Med Ctr Adults, Dept Pathol, Shiga, Japan
关键词
stent; restenosis; coronary artery disease; follow-up;
D O I
10.1002/ccd.20787
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We analyzed 14 cases of new lesions inside implanted bare-metal stents. In every case, there was no angiographic restenosis within 3 years, but a new lesion was observed inside a stented segment at long-term follow-up (> 5 years). Fourteen cases were evaluated: 9 with Wiktor stents, 2 with Palmaz-Schatz stents, and 3 with ACS Multilink stents. The interval from stent implantation to follow-up angiography was 63147 months (89 23). Thirteen lesions were treated by percutaneous coronary intervention (PCI) and stenotic tissue was obtained by directional coronary atherectomy (DCA) in 10 cases. All retrieved samples were composed of newly developed atherosclerosis facing the healed neointimal layer, and four samples showed histopathological findings of acute coronary syndrome. Stent struts were retrieved in four cases and no inflammation was observed surrounding them. Qualitative and quantitative analysis of stent struts was performed in two cases that showed no metal corrosion. These findings suggest that new atherosclerotic progression occurred inside the implanted stent without peristrut inflammation. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码:554 / 558
页数:5
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