Distinct subsets of human Vα24-invariant NKT cells:: cytokine responses and chemokine receptor expression

被引:88
作者
Kim, CH
Butcher, EC
Johnston, B
机构
[1] Purdue Univ, Biochem & Mol Biol Program, Dept Vet Pathobiol, Lab Immunol & Hematopoiesis, W Lafayette, IN 47907 USA
[2] Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA
[3] Vet Affairs Palo Alto Hlth Care Syst, Ctr Mol Biol & Med, Palo Alto, CA 94304 USA
基金
加拿大健康研究院;
关键词
D O I
10.1016/S1471-4906(02)02323-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD1d-restricted T-cell receptor Valpha-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.
引用
收藏
页码:516 / 519
页数:4
相关论文
共 25 条
[1]   A thymic precursor to the NK T cell lineage [J].
Benlagha, K ;
Kyin, T ;
Beavis, A ;
Teyton, L ;
Bendelac, A .
SCIENCE, 2002, 296 (5567) :553-555
[2]   Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire [J].
Campbell, JJ ;
Qin, SX ;
Unutmaz, D ;
Soler, D ;
Murphy, KE ;
Hodge, MR ;
Wu, LJ ;
Butcher, EC .
JOURNAL OF IMMUNOLOGY, 2001, 166 (11) :6477-6482
[3]  
Emoto M, 1999, J IMMUNOL, V162, P5094
[4]   NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance [J].
Faunce, DE ;
Stein-Streilein, J .
JOURNAL OF IMMUNOLOGY, 2002, 169 (01) :31-38
[5]   MIP-2 recruits NKT cells to the spleen during tolerance induction [J].
Faunce, DE ;
Sonoda, KH ;
Stein-Streilein, J .
JOURNAL OF IMMUNOLOGY, 2001, 166 (01) :313-321
[6]   NKT cells: facts, functions and fallacies [J].
Godfrey, DI ;
Hammond, KJL ;
Poulton, LD ;
Smyth, MJ ;
Baxter, AG .
IMMUNOLOGY TODAY, 2000, 21 (11) :573-583
[7]   Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining [J].
Gumperz, JE ;
Miyake, S ;
Yamamura, T ;
Brenner, MB .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :625-636
[8]   Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways [J].
Hayakawa, Y ;
Takeda, K ;
Yagita, H ;
Van Kaer, L ;
Saiki, I ;
Okumura, K .
JOURNAL OF IMMUNOLOGY, 2001, 166 (10) :6012-6018
[9]   Chemokines in rapid leukocyte adhesion triggering and migration [J].
Johnston, B ;
Butcher, EC .
SEMINARS IN IMMUNOLOGY, 2002, 14 (02) :83-92
[10]   Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells [J].
Kadowaki, N ;
Antonenko, S ;
Ho, S ;
Rissoan, MC ;
Soumelis, V ;
Porcelli, SA ;
Lanier, LL ;
Liu, YJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (10) :1221-1226