TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites

被引:495
作者
Sultan, AA
Thathy, V
Frevert, U
Robson, KJH
Crisanti, A
Nussenzweig, V
Nussenzweig, RS
Menard, R
机构
[1] NYU, MED CTR,MICHAEL HEIDELBERGER DIV IMMUNOL, DEPT PATHOL,KAPLAN CANC CTR, NEW YORK, NY 10016 USA
[2] NYU, MED CTR, DEPT MED & MOL PARASITOL, NEW YORK, NY 10016 USA
[3] JOHN RADCLIFFE HOSP, INST MOL MED, MRC, MOL HAEMATOL UNIT, OXFORD OX3 9DU, ENGLAND
[4] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT BIOL, LONDON SW7 2BB, ENGLAND
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0092-8674(00)80511-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many protozoans of the phylum Apicomplexa are invasive parasites that exhibit a substrate-dependent gliding motility. Plasmodium (malaria) sporozoites, the stage of the parasite that invades the salivary glands of the mosquito vector and the liver of the vertebrate host, express a surface protein called thrombospondin-related anonymous protein (TRAP) that has homologs in other Apicomplexa. By gene targeting in a rodent Plasmodium, we demonstrate that TRAP is critical for sporozoite infection of the mosquito salivary glands and the rat liver, and is essential for sporozoite gliding motility in vitro. This suggests that in Plasmodium sporozoites, and likely in other Apicomplexa, gliding locomotion and cell invasion have a common molecular basis.
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页码:511 / 522
页数:12
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