Expression of estrogen receptor β in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis

被引：165

作者：

Cheng, J ^{[1
]}

Lee, EJ ^{[1
]}

Madison, LD ^{[1
]}

Lazennec, G ^{[1
]}

机构：

[1] INSERM, U540, Mol & Cellular Endocrinol Canc, F-34090 Montpellier, France

来源：

FEBS LETTERS | 2004年 / 566卷 / 1-3期

关键词：

estrogen receptor; apoptosis; proliferation; invasion; prostate cancer;

D O I：

10.1016/j.febslet.2004.04.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The involvement of estrogen receptor beta (ER) in prostate carcinogenesis has been hypothesized. Several reports have shown that ER expression was decreased when prostate cells undergo neoplastic transformation, suggesting that it could play a tumor-suppressor role. By restoring ER expression in prostatic carcinoma cells by adenoviral delivery, we aimed to test this hypothesis. We observed that ER strongly inhibited the invasiveness and the growth of these cells. In addition, ER cells were undergoing apoptosis, as shown by quantification of Bax, Poly(ADP-ribose) polymerase and caspase-3 expression. Our data suggest that ER acts as a tumor-suppressor by its anti-proliferative, anti-invasive and pro-apoptotic properties. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：169 / 172

页数：4

共 27 条

[21]

Roger P, 2001, CANCER RES, V61, P2537

[22]

Sasaki M, 2002, J NATL CANCER I, V94, P384

[23] The complex genetic epidemiology of prostate cancer [J].

Schaid, DJ .

HUMAN MOLECULAR GENETICS, 2004, 13 :R103-R121

[24]

STROM A, 2004, P NATL AC SCI US

[25] Ligand-independent recruitment of SRC-1 to estrogen receptor β through phosphorylation of activation function AF-1 [J].

Tremblay, A ;

Tremblay, GB ;

Labrie, F ;

Giguère, V .

MOLECULAR CELL, 1999, 3 (04) :513-519

[26] An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and CYP7B1, regulates prostate growth [J].

Weihua, Z ;

Lathe, R ;

Warner, M ;

Gustafsson, JÅ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13589-13594

[27]

Weihua Zhang, 2001, Proceedings of the National Academy of Sciences of the United States of America, V98, P6330, DOI 10.1073/pnas.111150898

← 1 2 3 →