Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City

被引：371

作者：

Bradford, PA

Bratu, S

Urban, C

Visalli, M

Mariano, N

Landman, D

Rahal, JJ

Brooks, S

Cebular, S

Quale, J

机构：

[1] SUNY Downstate, Div Infect Dis, Brooklyn, NY 11203 USA

[2] Wyeth Res, Pearl River, NY USA

[3] Kingsbrook Jewish Med Ctr, Brooklyn, NY USA

[4] New York Hosp Queens, Flushing, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 01期

关键词：

D O I：

10.1086/421495

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenemhydrolyzing beta-lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta-lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta-lactamase in the United States.

引用

收藏

页码：55 / 60

页数：6

相关论文

共 33 条

[21] SME-type carbapenem-hydrolyzing class A β-lactamases from geographically diverse Serratia marcescens strains [J].

Queenan, AM ;

Torres-Viera, C ;

Gold, HS ;

Carmeli, Y ;

Eliopoulos, GM ;

Moellering, RC ;

Quinn, JP ;

Hindler, J ;

Medeiros, AA ;

Bush, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :3035-3039

[22] Glass restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella [J].

Rahal, JJ ;

Urban, C ;

Horn, D ;

Freeman, K ;

Segal-Maurer, S ;

Maurer, J ;

Mariano, N ;

Marks, S ;

Burns, JM ;

Dominick, D ;

Lim, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (14) :1233-1237

[23] IMIPENEM-RESISTANT AND MEROPENEM-RESISTANT MUTANTS OF ENTEROBACTER-CLOACAE AND PROTEUS-RETTGERI LACK PORINS [J].

RAIMONDI, A ;

TRAVERSO, A ;

NIKAIDO, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1174-1180

[24] Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae [J].

Rasmussen, BA ;

Bush, K ;

Keeney, D ;

Yang, YJ ;

Hare, R ;

OGara, C ;

Medeiros, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (09) :2080-2086

[25]

Sambrook J, 2001, MOL CLONING

[26] Antimicrobial resistance in Enterobacteriaceae in Brooklyn, NY: epidemiology and relation to antibiotic usage patterns [J].

Saurina, G ;

Quale, JM ;

Manikal, VM ;

Oydna, E ;

Landman, D .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (06) :895-898

[27]

TOLEMAN MA, 2002, 42 INT C ANT AG CHEM, P80

[28] Permeability to carbapenems of Proteus mirabilis mutants selected for resistance to imipenem or other beta-lactams [J].

Villar, HE ;

Danel, F ;

Livermore, DM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (03) :365-370

[29] Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes [J].

Wiener, J ;

Quinn, JP ;

Bradford, PA ;

Goering, RV ;

Nathan, C ;

Bush, K ;

Weinstein, RA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (06) :517-523

[30] Outbreak of infection with multidrug-resistant Klebsiella pneumoniae carrying blaIMP-8 in a university medical center in Taiwan [J].

Yan, JJ ;

Ko, WC ;

Tsai, SH ;

Wu, HM ;

Wu, JJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (12) :4433-4439

← 1 2 3 4 →