Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer

被引：78

作者：

Ruckhaeberle, Eugen ^{[1
]}

Karn, Thomas ^{[1
]}

Rody, Achim ^{[1
]}

Hanker, Lars ^{[1
]}

Gaetje, Regine ^{[1
]}

Metzler, Dirk ^{[2
]}

Holtrich, Uwe ^{[1
]}

Kaufmann, Manfred ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Dept Comp Sci & Math, D-60590 Frankfurt, Germany

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 08期

关键词：

Sphingolipid; Breast cancer; Microarray; CERK; UGT8; ST8SIA1; KILLER T-CELLS; ALPHA-GALACTOSYLCERAMIDE; PHASE-I; METASTASIS; VALIDATION; RESISTANCE; SIGNATURE; SPHINGOSINE-1-PHOSPHATE; IDENTIFICATION; ANGIOGENESIS;

D O I：

10.1007/s00432-008-0536-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer. Differences in expression of ceramide galactosyl transferase (UGT8), ceramide kinase (CERK), and Ganglioside GD3-Synthase (ST8SIA1) in breast cancer cells were investigated by using microarray data of 1,581 tumor samples. UGT8, CERK, and ST8SIA1 were associated with poor pathohistological grading (P < 0.001). High CERK expression was correlated with ErbB2 status (P = 0.006). Among ER positive breast cancers a significant worse prognosis for patients with tumors showing low ST8SIA1 and UGT8 expression was observed. In the ER negative subgroup those samples with high CERK expression displayed a worse prognosis. In a multivariate analysis only ST8SIA1 and tumor size remained significant. Our experiments reveal that expression of enzymes from the sphingolipid metabolism has prognostic implications in breast cancer.

引用

页码：1005 / 1013

页数：9

共 56 条

[1] Identification of high risk breast-cancer patients by gene expression profiling [J].

Ahr, A ;

Karn, T ;

Solbach, C ;

Seiter, T ;

Strebhardt, K ;

Holtrich, U ;

Kaufmann, M .

LANCET, 2002, 359 (9301) :131-132

[2] High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates [J].

Alexe, Gabricla ;

Dalgin, Gul S. ;

Scanfeld, Daniel ;

Tamayo, Pablo ;

Mesirov, Jill P. ;

DeLisi, Charles ;

Harris, Lyndsay ;

Barnard, Nicola ;

Martel, Maritza ;

Levine, Arnold J. ;

Ganesan, Shridar ;

Bhanot, Gyan .

CANCER RESEARCH, 2007, 67 (22) :10669-10676

[3] RETRACTED: Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial (Retracted Article. See vol 12, pg 116, 2011) [J].

不详 .

LANCET ONCOLOGY, 2007, 8 (12) :1071-1078

[4] Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice [J].

Dahm, F. ;

Bielawska, A. ;

Nocito, A. ;

Georgiev, P. ;

Szulc, Z. M. ;

Bielawski, J. ;

Jochum, W. ;

Dindo, D. ;

Hannun, Y. A. ;

Clavien, P-A .

BRITISH JOURNAL OF CANCER, 2008, 98 (01) :98-105

[5] Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series [J].

Desmedt, Christine ;

Piette, Fanny ;

Loi, Sherene ;

Wang, Yixin ;

d'assignies, Mahasti Saghatchian ;

Bergh, Jonas ;

Lidereau, Rosette ;

Ellis, Paul ;

Harris, Adrian L. ;

Klijn, Jan G. M. ;

Foekens, John A. ;

Cardoso, Fatima ;

Piccart, Martine J. ;

Buyse, Marc ;

Sotiriou, Christos .

CLINICAL CANCER RESEARCH, 2007, 13 (11) :3207-3214

[6] Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer [J].

Devalapally, Harikrishna ;

Duan, Zhenfeng ;

Seiden, Michael V. ;

Amiji, Mansoor M. .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (08) :1830-1838

[7] Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer [J].

Foekens, JA ;

Atkins, D ;

Zhang, Y ;

Sweep, FCGJ ;

Harbeck, N ;

Paradiso, A ;

Cufer, T ;

Sieuwerts, AM ;

Talantov, D ;

Span, PN ;

Tjan-Heijnen, VCG ;

Zito, AF ;

Specht, K ;

Hoefler, H ;

Golouh, R ;

Schittulli, F ;

Schmitt, M ;

Beex, LVAM ;

Klijn, IGM ;

Wang, YX .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (11) :1665-1671

[8] Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice [J].

Fujii, Shin-ichiro ;

Shimizu, Kanako ;

Hemmi, Hiroaki ;

Fukui, Mikiko ;

Bonito, Anthony J. ;

Chen, Guangwu ;

Franck, Richard W. ;

Tsuji, Moriya ;

Steinman, Ralph M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11252-11257

[9]

Giaccone G, 2002, CLIN CANCER RES, V8, P3702

[10] Going both ways: immune regulation via CD1d-dependent NKT cells [J].

Godfrey, DI ;

Kronenberg, M .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1379-1388

← 1 2 3 4 5 6 →