The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection

被引：38

作者：

Maeda, K

Nakata, H

Ogata, H

Koh, Y

Miyakawa, T

Mitsuya, H ^{[1
]}

机构：

[1] Kumamoto Univ, Sch Med, Dept Infect Dis, Kumamoto 8608556, Japan

[2] Kumamoto Univ, Sch Med, Dept Hematol, Kumamoto 8608556, Japan

[3] NCI, Expt Retrovirol Sect, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2004年 / 4卷 / 05期

关键词：

D O I：

10.1016/j.coph.2004.07.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The discovery of CCR5 as a HIV-1 co-receptor unfolded the cryptic and complicated process of HIV-1 cellular entry and has provided more than a few entry steps as possible modalities for effective viral intervention. The proof-of-principle has already been established for the use of entry inhibitors against HIV-1 and there is a cautious optimism that several CCR5 inhibitors might soon be added to our armamentarium for therapy of HIV-1 infection.

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收藏

页码：447 / 452

页数：6

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