The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection

被引：38

作者：

Maeda, K

Nakata, H

Ogata, H

Koh, Y

Miyakawa, T

Mitsuya, H ^{[1
]}

机构：

[1] Kumamoto Univ, Sch Med, Dept Infect Dis, Kumamoto 8608556, Japan

[2] Kumamoto Univ, Sch Med, Dept Hematol, Kumamoto 8608556, Japan

[3] NCI, Expt Retrovirol Sect, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2004年 / 4卷 / 05期

关键词：

D O I：

10.1016/j.coph.2004.07.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The discovery of CCR5 as a HIV-1 co-receptor unfolded the cryptic and complicated process of HIV-1 cellular entry and has provided more than a few entry steps as possible modalities for effective viral intervention. The proof-of-principle has already been established for the use of entry inhibitors against HIV-1 and there is a cautious optimism that several CCR5 inhibitors might soon be added to our armamentarium for therapy of HIV-1 infection.

引用

收藏

页码：447 / 452

页数：6

相关论文

共 66 条

[31] Membrane fusion [J].

Jahn, R ;

Lang, T ;

Südhof, TC .

CELL, 2003, 112 (04) :519-533

[32]

Kavlick MF, 2001, ANTIRETROVIRAL THERAPY, P279

[33] Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors [J].

Kazmierski, W ;

Bifulco, N ;

Yang, HB ;

Boone, L ;

DeAnda, F ;

Watson, C ;

Kenakin, T .

BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (13) :2663-2676

[34] Novel therapies based on mechanisms of HIV-1 cell entry [J].

Kilby, JM ;

Eron, JJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (22) :2228-2238

[35] Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody [J].

Kwong, PD ;

Wyatt, R ;

Robinson, J ;

Sweet, RW ;

Sodroski, J ;

Hendrickson, WA .

NATURE, 1998, 393 (6686) :648-659

[36] Antiretroviral-drug resistance among patients recently infected with HIV [J].

Little, SJ ;

Holte, S ;

Routy, JP ;

Daar, ES ;

Markowitz, M ;

Collier, AC ;

Koup, RA ;

Mellors, JW ;

Connick, E ;

Conway, B ;

Kilby, M ;

Wang, L ;

Whitcomb, JM ;

Hellmann, NS ;

Richman, DD .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (06) :385-394

[37] Chemokine receptors: Keys to AIDS pathogenesis? [J].

Littman, DR .

CELL, 1998, 93 (05) :677-680

[38] Frequency of CCR5 genotypes in HIV-infected patients in Roraima, Brazil [J].

Guerra Corado, Andre de Lima ;

Villarouco da Silva, George Allan ;

Carvalho Leao, Renato Augusto ;

Granja, Fabiana ;

Naveca, Felipe Gomes .

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2016, 20 (03) :314-315

[39] Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling:: A novel inhibitory mechanism of HIV infectivity [J].

Mack, M ;

Luckow, B ;

Nelson, PJ ;

Cihak, J ;

Simmons, G ;

Clapham, PR ;

Signoret, N ;

Marsh, M ;

Stangassinger, M ;

Borlat, F ;

Wells, TNC ;

Schlöndorff, D ;

Proudfoot, AEI .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) :1215-1224

[40] Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5 [J].

Maeda, K ;

Yoshimura, K ;

Shibayama, S ;

Habashita, H ;

Tada, H ;

Sagawa, K ;

Miyakawa, T ;

Aoki, M ;

Fukushima, D ;

Mitsuya, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :35194-35200

← 1 2 3 4 5 6 7 →