Hypoxia-induced miR-210 in epithelial ovarian cancer enhances cancer cell viability via promoting proliferation and inhibiting apoptosis

被引：67

作者：

Li, Li'an ^{[1
]}

Huang, Ke ^{[1
]}

You, Yanqin ^{[1
]}

Fu, Xiaoyu ^{[1
]}

Hu, Lingyun ^{[1
]}

Song, Lei ^{[1
]}

Meng, Yuanguang ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Obstet & Gynecol, Beijing 100853, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2014年 / 44卷 / 06期

关键词：

miR-210; hypoxia-inducible factor 1 alpha; epithelial ovarian cancer; apoptosis; tyrosine-protein phosphatase non-receptor type 1; INDEPENDENT PROGNOSTIC-FACTOR; GENE-EXPRESSION; MICRORNA SIGNATURE; LUNG-CANCER; PROTEIN; HIF-1-ALPHA; GROWTH; HIF-1; ANGIOGENESIS; MODULATION;

D O I：

10.3892/ijo.2014.2368

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

miR-210 is upregulated in a HIF-1 alpha-dependent way in several types of cancers. In addition, upregulated miR-210 promotes cancer proliferation, via its anti-apoptotic effects. It is blind to the regulation of miR-210 under hypoxia conditions for ovarian cancer cells and to the effect of miR-210 on ovarian cancer growth. In the present study, we determined the expression of miR-210 in epithelial ovarian cancer specimens, and in ovarian cancer cell lines under hypoxia conditions, and determined in detail the effect of miR-210 overexpression on tumor cell proliferation, and the possible mechanisms of tumor growth by miR-210 regulation. It was shown that miR-210 expression is upregulated, in response to hypoxia conditions in epithelial ovarian cancer specimens as well as epithelial ovarian cancer cell lines, with an association to HIF-1 alpha overexpression. Furthermore, upregulated miR-210 promoted tumor growth in vitro via targeting PTPN1 and inhibiting apoptosis. Therefore, our findings shed light on the mechanism of ovarian cancer adaptation to hypoxia.

引用

页码：2111 / 2120

页数：10

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