Dextromethorphan protects male but not female mice with brain ischemia

被引：15

作者：

Comi, Anne M.

Highet, Bridget H.

Mehta, Paulomi

Chong, Tae Hana

Johnston, Michael V.

Wilson, Mary Ann

机构：

[1] Kennedy Krieger Res Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA

[2] Kennedy Krieger Res Inst, Dept Neurosci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

NEUROREPORT | 2006年 / 17卷 / 12期

关键词：

carotid ligation; dextromethorphan; immature mouse; ischemia; N-methyl-D-aspartate receptor; sex-related neuroprotection;

D O I：

10.1097/01.wnr.0000220136.98918.41

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The non-competitive N-methyl-D-aspartate receptor antagonist dextromethorphan is protective against some types of brain injury. Unilateral carotid ligation in postnatal day 12 CDI mice produces ischemic brain injury. To evaluate the neuroprotective potential of dextromethorphan against ischemic injury in the immature brain, seven litters of postnatal day 12 CDI mice received either dextromethorphan or vehicle after a unilateral carotid ligation. Only the male pups were protected, and brain injury was unchanged in the female pups treated with dextromethorphan. These results suggest that clextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent.

引用

收藏

页码：1319 / 1322

页数：4

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