Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

被引:992
作者
Kabanov, Alexander V. [1 ,2 ,3 ]
Vinogradov, Serguei V. [1 ,2 ]
机构
[1] Univ Nebraska, Med Ctr, Coll Pharm, Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 68198 USA
[3] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899, Russia
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
drug delivery; nanogels; polyelectrolytes; polymers; polynucleotides; TRIBLOCK COPOLYMER ASSEMBLIES; ON-OFF REGULATION; DRUG-DELIVERY; NUCLEOSIDE ANALOGS; CROSS-LINKING; IN-VITRO; POLYELECTROLYTE MULTILAYERS; HYDROGEL NANOPARTICLES; ANTIGEN PRESENTATION; POLY(ACRYLIC ACID);
D O I
10.1002/anie.200900441
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanogels are swollen nanosized networks composed of hydrophilic or amphiphilic polymer chains. They are developed as carriers for the transport of drugs, and can be designed to spontaneously incorporate biologically active molecules through formation of salt bonds, hydrogen bonds, or hydrophobic interactions. Polyelectrolyte nanogels can readily incorporate oppositely charged low-molecular-mass drugs and biomacromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins. The guest molecules interact electrostatically with the ionic polymer chains of the gel and become bound within the finite nanogel. Multiple chemical functionalities can be employed in the nanogels to introduce imaging labels and to allow targeted drug delivery. The latter can be achieved, for example, with degradable or cleavable cross-links. Recent studies suggest that nanogels have a very promising future in biomedical applications. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:5418 / 5429
页数:12
相关论文
共 104 条
[1]   Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: Complexation and stabilization of insulin [J].
Akiyoshi, K ;
Kobayashi, S ;
Shichibe, S ;
Mix, D ;
Baudys, M ;
Kim, SW ;
Sunamoto, J .
JOURNAL OF CONTROLLED RELEASE, 1998, 54 (03) :313-320
[2]   Nano-engineering block copolymer aggregates for drug delivery [J].
Allen, C ;
Maysinger, D ;
Eisenberg, A .
COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) :3-27
[3]  
[Anonymous], 2005, ANGEW CHEM, DOI DOI 10.1002/ANGE.200462226
[4]   Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs [J].
Bontha, Satya ;
Kabanov, Alexander V. ;
Bronich, Tatiana K. .
JOURNAL OF CONTROLLED RELEASE, 2006, 114 (02) :163-174
[5]   Template-assisted synthesis of nanogels from Pluronic-modified poly(acrylic acid) [J].
Bronich, Tatiana K. ;
Bontha, Satya ;
Shlyakhtenko, Luda S. ;
Bromberg, Lev ;
Hatton, T. Alan ;
Kabanov, Alexander V. .
JOURNAL OF DRUG TARGETING, 2006, 14 (06) :357-366
[6]   Polymer micelle with cross-linked ionic core [J].
Bronich, TK ;
Keifer, PA ;
Shlyakhtenko, LS ;
Kabanov, AV .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (23) :8236-8237
[7]   Interaction of nanosized copolymer networks with oppositely charged amphiphilic molecules [J].
Bronich, TK ;
Vinogradov, SV ;
Kabanov, AV .
NANO LETTERS, 2001, 1 (10) :535-540
[8]  
Chang C, 2007, J BIOMAT SCI-POLYM E, V18, P1591
[9]  
Chen Haiyan, 2007, PDA J Pharm Sci Technol, V61, P303
[10]   Unique toroidal morphology from composition and sequence control of triblock copolymers [J].
Chen, ZY ;
Cui, HG ;
Hales, K ;
Li, ZB ;
Qi, K ;
Pochan, DJ ;
Wooley, KL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (24) :8592-8593