Comparison of an HXH three-center hydrogen bond with alternative two-center hydrogen bonds in a model system

被引：84

作者：

Yang, JH ^{[1
]}

Christianson, LA ^{[1
]}

Gellman, SH ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 01期

关键词：

D O I：

10.1021/ol9900010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Little information is available on the stability of three center hydrogen bonds relative to two center hydrogen bonds. In an XHX three center hydrogen bond, two donors interact with one acceptor; here, we compare an HXH interaction with the component two center hydrogen bonds (H-X and X-H) in a small depsipeptide, 1. The results show that there is negative cooperativity between the two components of the HXH interaction.

引用

页码：11 / 13

页数：3

共 43 条

[41] WATER-INSERTED ALPHA-HELICAL SEGMENTS IMPLICATE REVERSE TURNS AS FOLDING INTERMEDIATES [J].