Stitching together RNA tertiary architectures

被引:141
作者
Hermann, T [1 ]
Patel, DJ [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA
关键词
metal ions and hydration; ribozymes and catalysis; RNA folding and function; RNA motifs; X-ray; NMR; and molecular modeling;
D O I
10.1006/jmbi.1999.3312
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The powerful explanatory paradigm of molecular biology requiring form to co-evolve with function has again been proven successful when, over the recent two decades, a wealth of biological functions have been uncovered for RNA. Previously considered as a mere mediator of the genetic code, RNA is now acknowledged as a key player in a wide variety of cellular processes. Along with the discovery of novel biological functions of RNA molecules, a number of RNA three-dimensional structures have been solved which beautifully demonstrate the molecular adaptability which allows RNA to participate as a key player in these functions. A distinct repertoire of molecular motifs provides a basis for the assembly of complex RNA tertiary architectures. (C) 1999 Academic Press.
引用
收藏
页码:829 / 849
页数:21
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