Liver tumor characterization: Comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT - A multicenter trial

被引：144

作者：

Halavaara, J ^{[1
]}

Breuer, J ^{[1
]}

Ayuso, C ^{[1
]}

Balzer, T ^{[1
]}

Bellin, MF ^{[1
]}

Blomqvist, L ^{[1
]}

Carter, R ^{[1
]}

Grazioli, L ^{[1
]}

Hammerstingl, R ^{[1
]}

Huppertz, A ^{[1
]}

Jung, G ^{[1
]}

Krause, D ^{[1
]}

Laghi, A ^{[1
]}

Leen, E ^{[1
]}

Lupatelli, L ^{[1
]}

Marsili, L ^{[1
]}

Martin, J ^{[1
]}

Pretorius, ES ^{[1
]}

Reinhold, C ^{[1
]}

Stiskal, M ^{[1
]}

Stolpen, AH ^{[1
]}

机构：

[1] Jorvi Hosp, Dept Radiol, SF-02740 Espoo, Finland

来源：

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY | 2006年 / 30卷 / 03期

关键词：

liver; lesion; liver magnetic resonance; liver CT; magnetic resonance; contrast agent;

D O I：

10.1097/00004728-200605000-00001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

Objective: In our multicenter trial we compared the potentials of biphasic contrast-enhanced computed tomography (CT) and a novel tissue-specific magnetic resonance imaging (MRI) contrast agent gadoxetic acid disodium in liver lesion characterization. Methods: A total of 176 patients with 252 liver lesions were analyzed. There were 104 malignant and 148 benign lesions. High-field strength (1.0 T or 1.5 T) MR systems with T1-and T2-weighted sequences were used with and without fat suppression. After gadoxetic acid disodium injection, dynamic imaging and hepatocyte phase MR imaging were performed. Biphasic with 150 mg I/kg of body weight (100-200 mL) spiral CT was also performed. Image reading consisted of on-site (by study investigators) and fully blinded off-site (by E.S.P; C.R; and A.S) evaluations. The classification (benign or malignant) and characterization (lesion type) outcomes of both techniques were assessed. All imaging results were verified against a standard of reference. Results: Both on-site and off-site evaluations demonstrated increases in the lesion classification accuracy with gadoxetic acid disodium-enhanced MRI when compared with spiral CT. This improvement was also shown for characterization. Gadoxetic acid disodium was well tolerated. Conclusions: Gadoxetic acid disodium offers a safe and diagnostically powerful tool for the evaluation of patients with focal liver lesions with a reliable assessment of lesion classification and characterization.

引用

页码：345 / 354

页数：10

共 32 条

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