Phosphatidic acid- and phosphatidylserine-binding proteins

被引：323

作者：

Stace, Catherine L. ^{[1
]}

Ktistakis, Nicholas T. ^{[1
]}

机构：

[1] Babraham Inst, Signaling Programme, Cambridge CB2 4AT, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2006年 / 1761卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

lipid signaling; phosphatidic acid; phosphatidylserine; lipid recognition; phospholipase D;

D O I：

10.1016/j.bbalip.2006.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids with well-recognized structural roles in cellular membranes. They are also signaling lipids since their regulated formation (or appearance) can constitute an important signal for downstream responses. The list of potential effectors for these lipids is expanding rapidly and includes proteins involved in virtually all aspects of cellular regulation. Because it is not always clear whether these effectors recognize the specific phospholipids or a general negatively-charged membrane environment, questions about specificity must be addressed on a case by case basis. In this review we present an up to date list of potential phosphatidic acid- and phosphatidylserine-binding proteins. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：913 / 926

页数：14

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