Investigation of the Chemical Changes from Crude and Processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma Herbal Pair Extracts by Using Q Exactive High-Performance Benchtop Quadrupole-Orbitrap LC-MS/MS

被引：24

作者：

Cao, Gang ^{[1
,2
]}

Li, Qinglin ^{[3
]}

Cai, Hao ^{[1
]}

Tu, Sicong ^{[4
]}

Cai, Baochang ^{[1
,2
]}

机构：

[1] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Jiangsu, Peoples R China

[2] Zhejiang Chinese Med Univ, Res Ctr TCM Proc Technol, Hangzhou 310053, Zhejiang, Peoples R China

[3] Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

[4] Univ New S Wales, Fac Med, Sydney, NSW 2031, Australia

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷

基金：

中国国家自然科学基金;

关键词：

MULTIVARIATE STATISTICAL-ANALYSIS; PROFILING APPROACH; COMBINATION; GINSENG;

D O I：

10.1155/2014/170959

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

The Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair is mainly used for regulating the functions of liver and spleen, benefiting qi, and nourishing blood. However, the bioactive compounds for the pharmacological activities of the crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair extracts are still unclear to date. In the present study, Q Exactive high-performance benchtop quadrupole-Orbitrap LC-MS/MS was applied to identify the complicated components from crude and processed Paeoniae Radix Alba, crude and processed Atractylodis Macrocephalae Rhizoma, and their crude and processed herbal pair extracts. 123 and 101 compounds were identified in crude and processed Paeoniae Radix Alba samples, respectively. Meanwhile, 32 and 26 compounds were identified in crude and processed Atractylodis Macrocephalae Rhizoma samples, respectively. In the crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair extracts, co-decoction could significantly change the chemical composition of Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma in solution. The developed method may provide a scientific foundation for deeply elucidating the processing and compatibility mechanism of Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma.

引用

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