Antiplatelet prenylflavonoids from Artocarpus communis

被引：47

作者：

Weng, Jing-Ru

Chan, Sheng-Ching

Lu, Yi-Huang

Lin, Hsien-Cheng

Ko, Horng-Huey

Lin, Chun-Nan

机构：

[1] Kaohsiung Med Univ, Sch Technol Med Sci, Kaohsiung 807, Taiwan

[2] China Med Univ, Dept Biol Sci & Technol, Taichung 404, Taiwan

[3] Kaohsiung Med Unit, Sch Pharm, Kaohsiung 807, Taiwan

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 08期

关键词：

Artocarpus communis; Moraceae; flavonoids; antiplatelet effect;

D O I：

10.1016/j.phytochem.2006.01.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four flavonoids, dihydroartomunoxanthone (1), artomunoisoxanthone (2), cyclocomunomethonol (3) and artomunoflavanone (4), together with three known compounds, artochamins B (5), D and artocommunol CC (6) were isolated from the cortex of the roots of Artocarpus communis. The structures of 1-4 were determined by spectroscopic methods. The antiplatelet effects of the flavonoids, 1-3, 5 and 6 on human platelet-rich plasma (PRP) were evaluated. Of the compounds tested in human PRP, compounds 1, 5 and 6 showed significant inhibition of secondary aggregation induced by adrenaline. It is concluded that the antiplatelet effect of 1, 5 and 6 is mainly owing to an inhibitory effect on thromboxane formation. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：824 / 829

页数：6

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