Replicative senescence revisited

被引：60

作者：

Marcotte, R

Wang, E ^{[1
]}

机构：

[1] Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA

[2] McGill Univ, Bloomfield Ctr Res Aging, Lady Davis Inst Med Res, Sir Mortimer B Davis Jewish Gen Hosp, Montreal, PQ, Canada

[3] McGill Univ, Dept Med, Montreal, PQ, Canada

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2002年 / 57卷 / 07期

关键词：

D O I：

10.1093/gerona/57.7.B257

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening.

引用

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页码：B257 / B269

页数：13

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