Replicative senescence revisited

被引:60
作者
Marcotte, R
Wang, E [1 ]
机构
[1] Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA
[2] McGill Univ, Bloomfield Ctr Res Aging, Lady Davis Inst Med Res, Sir Mortimer B Davis Jewish Gen Hosp, Montreal, PQ, Canada
[3] McGill Univ, Dept Med, Montreal, PQ, Canada
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2002年 / 57卷 / 07期
关键词
D O I
10.1093/gerona/57.7.B257
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening.
引用
收藏
页码:B257 / B269
页数:13
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