Increased levels of serum and tissue miR-107 in human gastric cancer: Correlation with tumor hypoxia

被引：45

作者：

Ayremlou, Nooshin ^{[1
]}

Mozdarani, Hossein ^{[1
]}

Mowla, Seyed Javad ^{[2
]}

Delavari, Alireza ^{[3
]}

机构：

[1] Tarbiat Modares Univ, Dept Med Genet, Fac Med Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran, Iran

[3] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran

来源：

CANCER BIOMARKERS | 2015年 / 15卷 / 06期

关键词：

Gastric cancer; miR-107; hypoxia; MICRORNA EXPRESSION PATTERNS; CIRCULATING MICRORNAS; HEPATOCELLULAR-CARCINOMA; PROGNOSTIC-SIGNIFICANCE; SOLID TUMORS; MARKERS; PROLIFERATION; DEREGULATION; METASTASIS; BIOMARKERS;

D O I：

10.3233/CBM-150529

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

BACKGROUND: MicroRNAs can function as oncogenes and tumor suppressor genes in human cancers. The expression of miR-107 is high in various types of solid tumors. OBJECTIVE: The aim of this study was to evaluate the tumor and serum level of miR-107 and its correlation to HIF-1 alpha expression in gastric cancer patients. METHODS: Quantitative real-time PCR was used to analyze the expression of miR-107 and HIF-1a in 36 pairs of fresh gastric cancer and matched adjacent normal tissue specimens and the serum of these patients compared to age matched controls. RESULTS: The expression level of miR-107 was significantly higher in tumor tissues compared to adjacent normal tissue (p = 0.04). For serum, the expression level of miR-107 was significantly higher in gastric cancer patients than in age matched controls (p = 0.04). The correlation between tumor and serum expression of miR-107 with tumor hypoxia was found to be significant (p <= 0.001). CONCLUSION: The overexpression of miR-107 in tumors and serum of gastric cancer patients and its correlation with HIF-1a expression in tumor tissues was indicated that miR-107 may have a potential to use as a biomarker for detection of gastric cancer patients and hypoxia in gastric cancer tumor.

引用

页码：851 / 860

页数：10

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