Enzymatic cleavage and formation of cyanohydrins: a reaction of biological and synthetic relevance

被引：96

作者：

Griengl, H

Hickel, A

Johnson, DV

Kratky, C

Schmidt, M

Schwab, H

机构：

[1] GRAZ UNIV,INST PHYS CHEM,A-8010 GRAZ,AUSTRIA

[2] GRAZ TECH UNIV,INST ORGAN CHEM,A-8010 GRAZ,AUSTRIA

[3] GRAZ TECH UNIV,INST BIOTECHNOL,A-8010 GRAZ,AUSTRIA

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 20期

关键词：

D O I：

10.1039/a700907k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxynitrile lyases (Hnls) catalyse enantioselectively both the cleavage and formation of cyanohydrins, Besides the well known (R)-selective enzyme from almonds, (S)-Hnls have recently become available in larger quantities by cloning and over-expression. The first three-dimensional structure of a Hnl has been established for the enzyme from Hevea brasiliensis. These results are the basis for a still broader application of Hnls for biocatalytic asymmetric syntheses on a preparative scale.

引用

页码：1933 / 1940

页数：8