Chronic epi-inositol has an anxiolytic-like effect in the plus-maze model in rats

被引：21

作者：

Einat, H ^{[1
]}

Elkabaz-Shwortz, Z ^{[1
]}

Cohen, H ^{[1
]}

Kofman, O ^{[1
]}

Belmaker, RH ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva Mental Hlth Ctr, Beer Sheva, Israel

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 1998年 / 1卷 / 01期

关键词：

inositol; anxiety; plus-maze; behaviour;

D O I：

10.1017/S1461145798001035

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Behavioural effects of myo-inositol have been demonstrated in animal models of psychiatric disorders and in clinical trials in psychiatric patients. These effects of myo-inositol were thought to be consequences of its being a substrate for the enzyme phosphatidylinositol (PI) synthase. Recently, epi-inositol, an unnatural stereoisomer of myo-inositol that is not a substrate for PI synthase, was found to also have effects similar to those of myoinositol to reverse lithium-pilocarpine seizures. The present study measured the behaviour of rats in an elevated plus-maze model of anxiety after chronic treatment of 11 daily i.p. injections of epi-inositol, myo-inositol, or control solution. Epi-inositol reduced levels of anxiety-like behaviour in rats compared with controls, and its effect was stronger than that of myo-inositol. The increased relative effect of epi-inositol could be due to slower metabolism or to a different mechanism of action.

引用

页码：31 / 34

页数：4

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