Mesenteric afferent nerves are sensitive to vascular perfusion in a novel preparation of rat ileum in vitro

被引:15
作者
Brunsden, AM [1 ]
Jacob, S [1 ]
Bardhan, KD [1 ]
Grundy, D [1 ]
机构
[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2002年 / 283卷 / 03期
关键词
paravascular nerves; blood flow; capsaicin; neuraminidase;
D O I
10.1152/ajpgi.00343.2001
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Using novel in vitro preparations of vascularly perfused rat ileum, we investigated mesenteric afferent sensitivity to vascular perfusion. Gut (GPP) and vascular (VPP) perfusion pressures were recorded simultaneously with afferent discharge (AD). After preconstriction (L-phenylephrine), capsaicin (100 muM, gut lumen) caused a transient increase in AD and a sustained fall in VPP, supporting afferent modulation of vascular tone. In turn, AD was affected by vascular perfusion rate (VPR). Increasing VPR step-wise (0.6 to 1.0, 1.4 and 1.8 ml/min) caused concomitant falls in AD, returning at 0.6 ml/min. Terminating flow (5 min) increased AD. Afferent responses were independent of changes in GPP, vascular O-2, or the gut "tube" ("gut-off"). In gut-off studies, where capsaicin (100 nM ia) still reduced VPP, flow-associated falls in AD were abolished by the enzyme neuraminidase (0.2 U/ml ia or extravascularly over 20 min). In contrast, increased AD after stopped flow was unaffected. We propose that mesenteric afferents "sense" changes in vascular perfusion. The precise stimuli (pressure and/or flow) and the physiological relevance to control of local circulation remain to be determined.
引用
收藏
页码:G656 / G665
页数:10
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