Hypermethylation of tumor suppressor genes in cancer

被引：181

作者：

Herman, JG ^{[1
]}

机构：

[1] Johns Hopkins Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 05期

关键词：

DNA methylation; tumor suppressor genes; CpG island;

D O I：

10.1006/scbi.1999.0138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypermethylation of tumor suppressor genes and other genes functionally important in the neoplastic process is a recently recognized process. This epigenetic process is characterized by loss of function of these genes associated with transcriptional loss in the absence of structural alterations. The growing list of genes inactivated by promoter region hypermethylation provide an opportunity to examine the patterns of inactivation of such genes and provide clues as to the roles these events play in the neoplastic process.

引用

页码：359 / 367

页数：9

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