Hypermethylation of tumor suppressor genes in cancer

被引：181

作者：

Herman, JG ^{[1
]}

机构：

[1] Johns Hopkins Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 05期

关键词：

DNA methylation; tumor suppressor genes; CpG island;

D O I：

10.1006/scbi.1999.0138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypermethylation of tumor suppressor genes and other genes functionally important in the neoplastic process is a recently recognized process. This epigenetic process is characterized by loss of function of these genes associated with transcriptional loss in the absence of structural alterations. The growing list of genes inactivated by promoter region hypermethylation provide an opportunity to examine the patterns of inactivation of such genes and provide clues as to the roles these events play in the neoplastic process.

引用

页码：359 / 367

页数：9

共 104 条

[31] Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation [J].

Graff, JR ;

Herman, JG ;

Myohanen, S ;

Baylin, SB ;

Vertino, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) :22322-22329

[32]

GRAFF JR, 1995, CANCER RES, V55, P5195

[33] EPIGENETIC CHANGES MAY CONTRIBUTE TO THE FORMATION AND SPONTANEOUS REGRESSION OF RETINOBLASTOMA [J].

GREGER, V ;

PASSARGE, E ;

HOPPING, W ;

MESSMER, E ;

HORSTHEMKE, B .

HUMAN GENETICS, 1989, 83 (02) :155-158

[34]

Gurin CC, 1999, CANCER RES, V59, P462

[35]

Herfarth KKF, 1999, MOL CARCINOGEN, V24, P90, DOI 10.1002/(SICI)1098-2744(199902)24:2<90::AID-MC3>3.0.CO

[36]

2-B

[37]

Herman JG, 1996, CANCER RES, V56, P722

[38] Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma [J].

Herman, JG ;

Umar, A ;

Polyak, K ;

Graff, JR ;

Ahuja, N ;

Issa, JPJ ;

Markowitz, S ;

Willson, JKV ;

Hamilton, SR ;

Kinzler, KW ;

Kane, MF ;

Kolodner, RD ;

Vogelstein, B ;

Kunkel, TA ;

Baylin, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6870-6875

[39] SILENCING OF THE VHL TUMOR-SUPPRESSOR GENE BY DNA METHYLATION IN RENAL-CARCINOMA [J].

HERMAN, JG ;

LATIF, F ;

WENG, YK ;

LERMAN, MI ;

ZBAR, B ;

LIU, S ;

SAMID, D ;

DUAN, DSR ;

GNARRA, JR ;

LINEHAN, WM ;

BAYLIN, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9700-9704

[40]

Herman JG, 1997, CANCER RES, V57, P837

← 1 2 3 4 5 6 7 8 9 10 →