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Chemokines: directing leukocyte infiltration into allografts

被引：117
作者：
El-Sawy, T
Fahmy, NM
Fairchild, RL
机构：
[1] Cleveland Clin Fdn, Dept Immunol, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Inst Urol, Cleveland, OH 44195 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期
关键词：
D O I：
10.1016/S0952-7915(02)00382-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chemokines have been shown to play a critical role in the recruitment of leukocytes to transplanted organs. Animal models and clinical studies have demonstrated predictable temporal and spatial correlations between chemokine production and leukocyte infiltration into allografts. Antagonism of chemokines or chemokine receptors has been shown to delay leukocyte infiltration and prolong graft function, demonstrating an important role for chemokines in allograft rejection. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：562 / 568
页数：7
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共 43 条
  • [21] A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection
    Horuk, R
    Clayberger, C
    Krensky, AM
    Wang, ZH
    Gröne, HJ
    Weber, C
    Weber, KSC
    Nelson, PJ
    May, K
    Rosser, M
    Dunning, L
    Liang, M
    Buckmann, B
    Ghannam, A
    Ng, HP
    Islam, I
    Bauman, JG
    Wei, GP
    Monahan, S
    Xu, W
    Snider, RM
    Morrissey, MM
    Hesselgesser, J
    Perez, HD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (06) : 4199 - 4204
  • [22] Early expression of interferon-γ inducible protein 10 and monokine induced by interferon-γ in cardiac allografts is mediated by CD8+ T cells
    Kapoor, A
    Morita, K
    Engeman, TM
    Koga, S
    Vapnek, EM
    Hobart, MG
    Fairchild, RL
    [J]. TRANSPLANTATION, 2000, 69 (06) : 1147 - 1155
  • [23] Laskowski I, 2000, Ann Transplant, V5, P29
  • [24] Fractalkine is expressed by smooth muscle cells in response to IFN-γ and TNF-α and is modulated by metalloproteinase activity
    Ludwig, A
    Berkhout, T
    Moores, K
    Groot, P
    Chapman, G
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (02) : 604 - 612
  • [25] Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection
    Melter, M
    Exeni, A
    Reinders, MEJ
    Fang, JC
    McMahon, G
    Ganz, P
    Hancock, WW
    Briscoe, DM
    [J]. CIRCULATION, 2001, 104 (21) : 2558 - 2564
  • [26] Monokine induced by IFN-γ is a dominant factor directing T cells into murine cardiac allografts during acute rejection
    Miura, M
    Morita, K
    Kobayashi, H
    Hamilton, TA
    Burdick, MD
    Strieter, RM
    Fairchild, RL
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (06) : 3494 - 3504
  • [27] Neutralization of Groα and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury
    Miura, M
    Fu, X
    Zhang, QW
    Remick, DG
    Fairchild, RL
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (06) : 2137 - 2145
  • [28] Early chemokine cascades in murine cardiac grafts regulate T cell recruitment and progression of acute allograft rejection
    Morita, K
    Miura, M
    Paolone, DR
    Engeman, TM
    Kapoor, A
    Remick, DG
    Fairchild, RL
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (05) : 2979 - 2984
  • [29] Murphy PM, 2000, PHARMACOL REV, V52, P145
  • [30] TNF-α is a potent inducer for IFN-inducible protein-10 in hepatocytes and unaffected by GM-CSF in vivo, in contrast to IL-1β and IFN-γ
    Narumi, S
    Yoneyama, H
    Inadera, H
    Nishioji, K
    Itoh, Y
    Okanoue, T
    Matsushima, K
    [J]. CYTOKINE, 2000, 12 (07) : 1007 - 1016
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