Enzymatic kinetic resolution of (+/-)-4-acetoxy[2.2]paracyclophane by Candida cylindracea lipase. An efficient route for the preparation of (+)-R-4-hydroxy- and (+)-S-4-acetoxy[2.2]paracyclophane

被引：34

作者：

Cipiciani, A ^{[1
]}

Fringuelli, F ^{[1
]}

Mancini, V ^{[1
]}

Piermatti, O ^{[1
]}

Scappini, AM ^{[1
]}

Ruzziconi, R ^{[1
]}

机构：

[1] UNIV BASILICATA,DIPARTIMENTO CHIM,I-85100 POTENZA,ITALY

来源：

TETRAHEDRON | 1997年 / 53卷 / 34期

关键词：

D O I：

10.1016/S0040-4020(97)00758-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enzymatic kinetic resolution of (+/-)-4-acetoxy[2.2]paracyclophane by Candida cylindracea lipase was investigated in water and in a tea-phase aqueous organic system. The (+)-(R)-4-hydroxy- and (+)-(S)-4-acetoxyl[2,2]-paracyclophanes were isolated in excellent yields and high enantiomeric excesses. The resolution was carried out on multi-gram scale in hexane-water at 40 degrees C. (C) 1997 Elsevier Science Ltd.

引用

页码：11853 / 11858

页数：6