Synthesis of new halo-containing acetylenes and their application to the synthesis of azoles

被引：33

作者：

Martins, MAP ^{[1
]}

Emmerich, DJ ^{[1
]}

Pereira, CMP ^{[1
]}

Cunico, W ^{[1
]}

Rossato, M ^{[1
]}

Zanatta, N ^{[1
]}

Bonacorso, HG ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Nucl Quim Heterociclos, NUQHIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 25期

关键词：

acetylenes; heterocycles; pyrazoles; isoxazoles;

D O I：

10.1016/j.tetlet.2004.04.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The convenient synthesis of ten halo- and an isoxazole-containing acetylenes from the reaction of acetylenes with n-butyl lithium and Subsequent reaction with an electrophile agent (ethyl trichloroacetate, ethyl dichloroacetate, trifluoroacetic anhydride, 3-methylisoxazol-5-carbonyl chloride, carbon tetrachloride and 1,1,1-trifluoro-o-4-ethoxy-3-buten-2-one) in moderated to good yields is reported. The application of 1,1,1-trichloro-4-phenyl-3-butyn-2-one on the synthesis of two azoles is also showed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4935 / 4938

页数：4

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