Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014

被引：67

作者：

Blyth, C. C. ^{[1
,2
,3
,4
]}

Gilroy, N. M. ^{[5
,6
]}

Guy, S. D. ^{[7
]}

Chambers, S. T. ^{[8
,9
]}

Cheong, E. Y. ^{[10
]}

Gottlieb, T. ^{[10
]}

McGuinness, S. L. ^{[11
]}

Thursky, K. A. ^{[12
,13
]}

机构：

[1] Univ Western Australia, Sch Paediat & Child Hlth, Perth, WA 6009, Australia

[2] Princess Margaret Hosp Children, Dept Gen Paediat, Subiaco, WA, Australia

[3] PathWest Lab Med WA, Subiaco, WA, Australia

[4] Univ Western Australia, Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth, WA 6009, Australia

[5] Agcy Clin Innovat, Blood & Marrow Transplant BMT Network, Chatswood, NSW, Australia

[6] St Vincents Hosp, Dept Infect Dis & Clin Microbiol, Darlinghurst, NSW 2010, Australia

[7] Western Hlth, Dept Infect Dis, Footscray, Vic, Australia

[8] Univ Otago, Dept Pathol, Christchurch, New Zealand

[9] Christchurch Hosp, Dept Infect Dis, Christchurch, New Zealand

[10] Concord Repatriat Gen Hosp, Infect Dis & Microbiol Dept, Concord, NSW, Australia

[11] Royal Darwin Hosp, Dept Infect Dis, Tiwi, NT, Australia

[12] Peter MacCallum Canc Ctr, Dept Infect Dis & Infect Control, East Melbourne, Vic 8006, Australia

[13] Doherty Inst Infect & Immun, Victorian Infect Dis Serv, Parkville, Vic, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2014年 / 44卷 / 12B期

关键词：

invasive mould disease; antifungal therapy; aspergillosis; mucormycosis; emerging fungal infection; LIPOSOMAL AMPHOTERICIN-B; VITRO ANTIFUNGAL SUSCEPTIBILITY; DISSEMINATED FUSARIUM INFECTION; NERVOUS-SYSTEM ASPERGILLOSIS; ACUTE MYELOID-LEUKEMIA; IN-VITRO; FUNGAL-INFECTIONS; COMBINATION THERAPY; SALVAGE THERAPY; NEUTROPENIC PATIENT;

D O I：

10.1111/imj.12598

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mould species represent the pathogens most commonly associated with invasive fungal disease in patients with haematological malignancies and patients of haemopoietic stem cell transplants. Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While Aspergillus species remain the most prevalent cause of invasive mould infections, Scedosporium and Fusarium species and the Mucormycetes continue to place a significant burden on the immunocompromised host. Evidence also suggests that infections caused by rare and emerging pathogens are increasing within the setting of broad-spectrum antifungal prophylaxis and improved survival times placing immunosuppressed patients at risk for longer. These guidelines present evidence-based recommendations for the antifungal management of common, rare and emerging mould infections in both adult and paediatric populations. Where relevant, the role of surgery, adjunctive therapy and immunotherapy is also discussed.

引用

页码：1333 / 1349

页数：17

共 148 条

[1] Invasive pulmonary infection due to Trichoderma longibrachiatum mimicking invasive aspergillosis in a neutropenic patient successfully treated with voriconazole combined with caspofungin [J].