Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors

被引：118

作者：

Short, JJ

Pereboev, AV

Kawakami, Y

Vasu, C

Holterman, MJ

Curiel, DT

机构：

[1] Univ Alabama, Gene Therapy Ctr, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Med, Div Human Gene Therapy, Birmingham, AL 35294 USA

[3] Univ Alabama, Dept Pathol, Div Human Gene Therapy, Birmingham, AL 35294 USA

[4] Univ Alabama, Dept Surg, Div Human Gene Therapy, Birmingham, AL 35294 USA

[5] Univ Illinois, Dept Surg, Chicago, IL 60612 USA

[6] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA

来源：

VIROLOGY | 2004年 / 322卷 / 02期

关键词：

adenovirus; receptor; CD80; CD86; subgroup B; co-stimulatory molecules;

D O I：

10.1016/j.virol.2004.02.016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Most viruses exploit a variety of host cellular proteins as primary cellular attachment receptors in the context of successful execution of infection. Furthermore, many viral agents have evolved precise mechanisms to subvert host immune recognition to achieve persistence. Herein we present data indicating that adenovirus (Ad) serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. CD80 and CD86 are co-stimulatory molecules that are present on mature dendritic cells and B lymphocytes and are involved in stimulating T-lymphocyte activation. To our knowledge, this is one of the first demonstrations of a virus utilizing immunologic accessory molecules as a primary means of cellular entry. This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：349 / 359

页数：11

共 49 条

[31] The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F [J].