GSTT1 null genotype increases risk of premenopausal breast cancer

被引：23

作者：

Matheson, MC ^{[1
]}

Stevenson, T

Akbarzadeh, S

Propert, DN

机构：

[1] Alfred Hosp, Cent & Eastern Clin Sch, Dept Epidemiol & Prevent Med, Melbourne, Vic 3151, Australia

[2] RMIT Univ, Dept Appl Biol & Biotechnol, Melbourne, Vic 3151, Australia

[3] Peter MacCallum Canc Inst, Melbourne, Vic 3000, Australia

[4] RMIT Univ, Dept Appl Biol & Biotechnol, Melbourne, Vic, Australia

来源：

CANCER LETTERS | 2002年 / 181卷 / 01期

关键词：

premenopausal breast cancer; glutathione S-transferase; N-acetyltransferase; polymorphisms;

D O I：

10.1016/S0304-3835(02)00046-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The NAT2, GSTM1 and GSTT1 genes are known candidate cancer susceptibility markers and have been investigated in breast cancer susceptibility with conflicting results. We conducted a case-control study to investigate the role of NAT2, GSTM1 and GSTT1 in premenopausal breast cancer. Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. Our results suggest that the GSTT1 null genotype may play a role in early onset breast cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：73 / 79

页数：7

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