Effects of losartan treatment on the physicochemical properties of diabetic rat bone

被引:17
作者
Donmez, Baris Ozgur [1 ]
Unal, Mustafa [2 ]
Ozdemir, Semir [3 ]
Ozturk, Nihal [3 ]
Oguz, Nurettin [4 ]
Akkus, Ozan [2 ]
机构
[1] Akdeniz Univ, Dept Nutr & Dietet, Sch Hlth, TR-07070 Antalya, Turkey
[2] Case Western Reserve Univ, Dept Mech & Aerosp Engn, Orthopaed Bioengn Labs, Cleveland, OH 44106 USA
[3] Akdeniz Univ, Dept Biophys, Fac Med, Antalya, Turkey
[4] Akdeniz Univ, Dept Anat, Fac Med, Antalya, Turkey
关键词
Bone; Losartan; Diabetes mellitus; Osteopenia; Renin-angiotensin system; RENIN-ANGIOTENSIN SYSTEM; COLLAGEN CROSS-LINKS; CONVERTING ENZYME-INHIBITOR; AGE-RELATED-CHANGES; MINERAL DENSITY; FRACTURE RISK; CANCELLOUS BONE; HIP FRACTURE; OSTEOPOROSIS; MELLITUS;
D O I
10.1007/s00774-016-0748-9
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Inhibitors of the renin-angiotensin system used to treat several diseases have also been shown to be effective on bone tissue, suggesting that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may reduce fracture risk. The present study investigated the effects of losartan on the physicochemical and biomechanical properties of diabetic rat bone. Losartan (5 mg/kg/day) was administered via oral gavage for 12 weeks. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Whole femurs were tested under tension to evaluate the biomechanical properties of bone. The physicochemical properties of bone were analyzed by Fourier transform infrared spectroscopy. Although losartan did not recover decreases in the BMD of diabetic bone, it recovered the physicochemical (mineral and collagen matrix) properties of diabetic rat bone. Furthermore, losartan also recovered ultimate tensile strength of diabetic rat femurs. Losartan, an angiotensin II type 1 receptor blocker, has a therapeutic effect on the physicochemical properties of diabetic bone resulting in improvement of bone strength at the material level. Therefore, specific inhibition of this pathway at the receptor level shows potential as a therapeutic target for diabetic patients suffering from bone diseases such as osteopenia.
引用
收藏
页码:161 / 170
页数:10
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