Magnesium mediated carbometallation of propargyl alcohols: direct routes to dihydroxydienes and enediyne alcohols

被引：31

作者：

Forgione, P ^{[1
]}

Fallis, AG ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

diene; diol; magnesium; propargyl; enediyne;

D O I：

10.1016/S0040-4039(99)01994-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of vinyl and alkynyl Grignard reagents to propargyl alcohols for the direct synthesis of dihydroxydienes and enediyne alcohols from a one pot reaction is described. These products arise from the putative magnesium chelate intermediate 2 upon reaction with the appropriate electrophile. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：11 / 15

页数：5

共 32 条

[1]

Borders D B, 1995, ENEDIYNE ANTIBIOTICS

[2]

CHEREST M, 1966, TETRAHEDRON LETT, P875

[3] STEREOSELECTIVE SYNTHESIS OF POLYSUBSTITUTED OLEFINS VIA THE FORMATION OF 1,1-BIMETALLOALKENES [J].