Mast cell production and response to IL-4 and IL-13

被引：195

作者：

McLeod, Jamie J. A. ^{[1
]}

Baker, Bianca ^{[1
]}

Ryan, John J. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA

来源：

CYTOKINE | 2015年 / 75卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Mast cells; Interleukin-4; IL-4; Interleukin-13; IL-13; FC-EPSILON-RI; NECROSIS-FACTOR-ALPHA; GENE-EXPRESSION; CYTOKINE PRODUCTION; NUCLEAR-FACTOR; MESSENGER-RNA; STAT6; ISOFORM; CUTTING EDGE; FACTOR-I; C-KIT;

D O I：

10.1016/j.cyto.2015.05.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4R alpha, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：57 / 61

页数：5

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