3-epi-aplykurodinone B, a new degraded sterol from Aplysia fasciata

被引：27

作者：

Ortega, MJ ^{[1
]}

Zubia, E ^{[1
]}

Salva, J ^{[1
]}

机构：

[1] UNIV CADIZ,FAC CIENCIAS MAR,DEPT QUIM ORGAN,E-11510 PUERTO REAL,CADIZ,SPAIN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 05期

关键词：

D O I：

10.1021/np9607464

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The anaspidean mollusk Aplysia fasciata from Rio San Pedro (Cadiz, Spain) contains the known degraded sterols aplykurodinone B (2) and aplykurodin B (4) together with the new 3-epi-aplykurodinone B (5). The structure of 5 was elucidated by interpretation of spectral data, and its relative stereochemistry was established using NOEDS experiments. The new compound 5 exhibited cytotoxicity against four tumor cell lines.

引用

页码：488 / 489

页数：2

共 3 条

[1] CONTIGNASTEROL, A HIGHLY OXYGENATED STEROID WITH THE UNNATURAL 14-BETA CONFIGURATION FROM THE MARINE SPONGE PETROSIA-CONTIGNATA THIELE, 1899 [J].

BURGOYNE, DL ;

ANDERSEN, RJ ;

ALLEN, TM .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (02) :525-528

[2] ISOLATION AND STRUCTURES OF APLYKURODINS-A AND APLYKURODINS-B, 2 NEW ISOPRENOIDS FROM THE MARINE MOLLUSK APLYSIA-KURODAI [J].

MIYAMOTO, T ;

HIGUCHI, R ;

KOMORI, T ;

FUJIOKA, T ;

MIHASHI, K .

TETRAHEDRON LETTERS, 1986, 27 (10) :1153-1156

[3] 4-ACETYLAPLYKURODIN-B AND APLYKURODINONE-B, 2 ICHTHYOTOXIC DEGRADED STEROLS FROM THE MEDITERRANEAN MOLLUSK APLYSIA-FASCIATA [J].

SPINELLA, A ;

GAVAGNIN, M ;

CRISPINO, A ;

CIMINO, G ;

MARTINEZ, E ;

ORTEA, J ;

SODANO, G .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (07) :989-993

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