Two novel vaginal microbicides (polystyrene sulfonate and cellulose sulfate) inhibit Gardnerella vaginalis and anaerobes commonly associated with bacterial vaginosis

被引：46

作者：

Simoes, JA

Citron, DM

Aroutcheva, A

Anderson, RA

Chany, CJ

Waller, DP

Faro, S

Zaneveld, LJD

机构：

[1] Rush Univ, Dept Obstet & Gynecol, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Pharmaceut & Pharmacodynam, Chicago, IL USA

[3] State Univ Campinas, Dept Obstet & Gynecol, Sao Paulo, Brazil

[4] RM Alden Res Lab, Santa Monica, CA USA

[5] Univ Texas, Hlth Sci Ctr, Dept Obstet & Gynecol, Houston, TX USA

[6] Womans Hosp Texas, Houston, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2692-2695.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This is the first report demonstrating the in vitro inhibitory activity of two novel microbicides (cellulose sulfate and polystyrene sulfonate) against bacterial vaginosis (BV)-associated bacteria. Vaginal application of these microbicides not only may reduce the risk of acquisition of human immunodeficiency virus and other sexually transmitted infection-causing organisms but may also decrease the incidence of BV.

引用

页码：2692 / 2695

页数：4

共 26 条

[1]

Anderson RA, 2000, J ANDROL, V21, P862

[2]

Anderson RA, 2002, J ANDROL, V23, P426

[3] SULFATED POLYSACCHARIDES ARE POTENT AND SELECTIVE INHIBITORS OF VARIOUS ENVELOPED VIRUSES, INCLUDING HERPES-SIMPLEX VIRUS, CYTOMEGALO-VIRUS, VESICULAR STOMATITIS-VIRUS, AND HUMAN IMMUNODEFICIENCY VIRUS [J].