Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome

被引：18

作者：

Wakana, S

Sugaya, E

Naramoto, F

Yokote, N

Maruyama, C

Jin, W

Ohguchi, H

Tsuda, T

Sugaya, A

Kajiwara, K

机构：

[1] Tokai Univ, Sch Med, Tokyo Hosp, Div Oriental Med,Shibuya Ku, Tokyo 1510053, Japan

[2] Cent Inst Expt Anim, Kanagawa, Japan

[3] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 35002, Japan

[4] Tokai Univ, Inst Med, Div Mol & Dev Sci, Kanagawa 2591100, Japan

来源：

BRAIN RESEARCH | 2000年 / 857卷 / 1-2期

关键词：

SEZ gene; gene mapping; pentylenetetrazol susceptible QTL; linkage analysis; seizure; epilepsy;

D O I：

10.1016/S0006-8993(99)02406-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gene mapping of the newly discovered SEZ genes (seizure-related genes) in the mouse was performed by linkage analysis. SEZ6 was on chromosome 11, SEZ12 on chromosome 16, SEZ15 on chromosome 3 and SEZ17 (PTZ17) on chromosome 18. The mouse chromosomal locus related to high susceptibility to pentylenetetrazol (PTZ) was also determined by linkage analysis using the recombinant inbred mouse. BXD (C57BL X DBA). A significant level of PTZ susceptibility was found on chromosome 2. Chromosomal loci of the newly discovered SEZ genes were not coincident with the significant chromosomal loci to PTZ susceptibility. Since epilepsy is assumed to be a disease syndrome which is probably manifested by abnormal expression of multifocal genes, determination of the role of each chromosomal locus in the provocation of seizure activity is important. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：286 / 290

页数：5

共 21 条

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