Making medicinal chemistry more effective-application of Lean Sigma to improve processes, speed and quality

被引：53

作者：

Andersson, Shalini ^{[1
]}

Armstrong, Alan ^{[2
]}

Bjore, Annika ^{[1
]}

Bowker, Sue ^{[3
]}

Chapman, Steve ^{[3
]}

Davies, Rob ^{[3
]}

Donald, Craig ^{[3
]}

Egner, Bryan ^{[1
]}

Elebring, Thomas ^{[1
]}

Holmqvist, Sara ^{[1
]}

Inghardt, Tord ^{[1
]}

Johannesson, Petra ^{[1
]}

Johansson, Magnus ^{[1
]}

Johnstone, Craig ^{[3
]}

Kemmitt, Paul ^{[3
]}

Kihlberg, Jan ^{[1
]}

Korsgren, Pernilla ^{[1
]}

Lemurell, Malin ^{[1
]}

Moore, Jane ^{[3
]}

Pettersson, Jonas A. ^{[4
]}

Pointon, Helen ^{[3
]}

Ponten, Fritiof ^{[1
]}

Schofield, Paul ^{[3
]}

Selmi, Nidhal ^{[3
]}

Whittamore, Paul ^{[3
]}

机构：

[1] AstraZeneca R&D, Med Chem, SE-43183 Molndal, Sweden

[2] AstraZeneca R&D Alderley Pk, Mereside, DECS, Continuous Improvement, Alderley Edge SK10 4TG, England

[3] AstraZeneca R&D Alderley Pk, Mereside, CVGI Chem, Alderley Edge SK10 4TG, England

[4] AstraZeneca R&D, DECS, Continuous Improvement, SE-43183 Molndal, Sweden

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 11-12期

关键词：

RESEARCH-AND-DEVELOPMENT; DRUG DISCOVERY; OPTIMIZATION;

D O I：

10.1016/j.drudis.2009.03.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmaceutical industry, particularly the small molecule domain, faces unprecedented challenges of escalating costs, high attrition as well as increasing competitive pressure from other companies and from new treatment modes such as biological products. In other industries, process improvement approaches, such as Lean Sigma, have delivered benefits in speed, quality and cost of delivery. Examining the medicinal chemistry contributions to the iterative improvement process of design-make-test-analyse from a Lean Sigma perspective revealed that major improvements could be made. Thus, the cycle times of synthesis, as well as compound analysis and purification, were reduced dramatically. Improvements focused on team, rather than individual, performance. These new ways of working have consequences for staff engagement, goals, rewards and motivation, which are also discussed.

引用

页码：598 / 604

页数：7

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