New features of mitochondrial DNA replication system in yeast and man

被引:79
作者
Lecrenier, N [1 ]
Foury, F [1 ]
机构
[1] Univ Catholique Louvain, Unite Biochim Physiol, B-1348 Louvain, Belgium
关键词
genome; Homo sapiens; mitochondria; polymerase; Saccharomyces cerevisiae;
D O I
10.1016/S0378-1119(00)00107-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In this review, we sum up the research carried out over two decades on mitochondrial DNA (mtDNA) replication, primarily by comparing this system in Saccharomyces cerevisiae and Homo sapiens. Brief incursions into systems of other organisms have also been achieved when they provide new information. S. cerevisiae and N. sapiens mitochondrial DNA (mtDNA) have been thought for a long time to share closely related architecture and replication mechanisms. However, recent studies suggest that mitochondrial genome of S. cerevisiae may be formed, at least partially, from linear multimeric molecules, while human mtDNA is circular. Although several proteins involved in the replication of these two genomes are very similar, divergences are also now increasingly evident. As an example, the recently cloned human mitochondrial DNA polymerase beta-subunit has no counterpart in yeast. Yet, yeast Abf2p and human mtTFA are probably not as closely functionally related as thought previously. Some mtDNA metabolism factors, like DNA ligases, were until recently largely uncharacterized, and have been found to be derived from alternative nuclear products. Many factors involved in the metabolism of mitochondrial DNA are linked through genetic or biochemical interconnections. These links are presented on a may. Finally, we discuss recent studies suggesting that the yeast mtDNA replication system diverges from that observed in man, and may involve recombination, possibly coupled to alternative replication mechanisms like rolling circle replication. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:37 / 48
页数:12
相关论文
共 104 条
  • [41] ESSENTIAL ROLE OF THE HMG DOMAIN IN THE FUNCTION OF YEAST MITOCHONDRIAL HISTONE HM - FUNCTIONAL COMPLEMENTATION OF HM BY THE NUCLEAR NONHISTONE PROTEIN NHP6A
    KAO, LR
    MEGRAW, TL
    CHAE, CB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) : 5598 - 5602
  • [42] Kao LR, 1996, YEAST, V12, P1239, DOI 10.1002/(SICI)1097-0061(19960930)12:12<1239::AID-YEA17>3.0.CO
  • [43] 2-8
  • [44] Rolling-circle replication of bacterial plasmids
    Khan, SA
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1997, 61 (04) : 442 - +
  • [45] PIF-1 - A DNA HELICASE IN YEAST MITOCHONDRIA
    LAHAYE, A
    STAHL, H
    THINESSEMPOUX, D
    FOURY, F
    [J]. EMBO JOURNAL, 1991, 10 (04) : 997 - 1007
  • [46] Lakshmipathy U, 1999, MOL CELL BIOL, V19, P3869
  • [47] Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
    Larsson, NG
    Wang, JM
    Wilhelmsson, H
    Oldfors, A
    Rustin, P
    Lewandoski, M
    Barsh, GS
    Clayton, DA
    [J]. NATURE GENETICS, 1998, 18 (03) : 231 - 236
  • [48] LOW-LEVELS OF MITOCHONDRIAL TRANSCRIPTION FACTOR-A IN MITOCHONDRIAL-DNA DEPLETION
    LARSSON, NG
    OLDFORS, A
    HOLME, E
    CLAYTON, DA
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (03) : 1374 - 1381
  • [49] Mitochondrial DNA polymerases from yeast to man: A new family of polymerases
    Lecrenier, N
    VanDerBruggen, P
    Foury, F
    [J]. GENE, 1997, 185 (01) : 147 - 152
  • [50] OVEREXPRESSION OF THE RNR1 GENE RESCUES SACCHAROMYCES-CEREVISIAE MUTANTS IN THE MITOCHONDRIAL-DNA POLYMERASE-ENCODING MIP1 GENE
    LECRENIER, N
    FOURY, F
    [J]. MOLECULAR & GENERAL GENETICS, 1995, 249 (01): : 1 - 7