Making ends meet: Repairing breaks in bacterial DNA by non-homologous end-joining

被引：151

作者：

Bowater, Richard

Doherty, Aidan J. ^{[1
]}

机构：

[1] Univ Sussex, Gen Damage & Stabil Ctr, Falmer, England

[2] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

来源：

PLOS GENETICS | 2006年 / 2卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1371/journal.pgen.0020008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukaryotes: homologous recombination and non-homologous end-joining (NHEJ). Until very recently, the NHEJ pathway had been thought to be restricted to the eukarya. However, an evolutionarily related NHEJ apparatus has now been identified and characterized in the prokarya. Here we review the recent discoveries concerning bacterial NHEJ and discuss the possible origins of this repair system. We also examine the insights gained from the recent cellular and biochemical studies of this DSB-repair process and discuss the possible cellular roles of an NHEJ pathway in the life-cycle of prokaryotes and phages. © 2006 Bowater and Doherty.

引用

页码：93 / 99

页数：7

共 61 条

[1] LOCALIZATION OF THE GAM GENE OF BACTERIOPHAGE-MU AND CHARACTERIZATION OF THE GENE-PRODUCT [J].

AKROYD, J ;

SYMONDS, N .

GENE, 1986, 49 (02) :273-282

[2] Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system [J].

Aravind, L ;

Koonin, EV .

GENOME RESEARCH, 2001, 11 (08) :1365-1374

[3] Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].

Bentley, SD ;

Chater, KF ;

Cerdeño-Tárraga, AM ;

Challis, GL ;

Thomson, NR ;

James, KD ;

Harris, DE ;

Quail, MA ;

Kieser, H ;

Harper, D ;

Bateman, A ;

Brown, S ;

Chandra, G ;

Chen, CW ;

Collins, M ;

Cronin, A ;

Fraser, A ;

Goble, A ;

Hidalgo, J ;

Hornsby, T ;

Howarth, S ;

Huang, CH ;

Kieser, T ;

Larke, L ;

Murphy, L ;

Oliver, K ;

O'Neil, S ;

Rabbinowitsch, E ;

Rajandream, MA ;

Rutherford, K ;

Rutter, S ;

Seeger, K ;

Saunders, D ;

Sharp, S ;

Squares, R ;

Squares, S ;

Taylor, K ;

Warren, T ;

Wietzorrek, A ;

Woodward, J ;

Barrell, BG ;

Parkhill, J ;

Hopwood, DA .

NATURE, 2002, 417 (6885) :141-147

[4] Stress-induced mutagenesis in bacteria [J].

Bjedov, I ;

Tenaillon, O ;

Gérard, B ;

Souza, V ;

Denamur, E ;

Radman, M ;

Taddei, F ;

Matic, I .

SCIENCE, 2003, 300 (5624) :1404-1409

[5] INTEGRATION AND EXCISION OF SV40 DNA FROM THE CHROMOSOME OF A TRANSFORMED-CELL [J].

BOTCHAN, M ;

STRINGER, J ;

MITCHISON, T ;

SAMBROOK, J .

CELL, 1980, 20 (01) :143-152

[6] The role of DNA damage in stationary phase ('adaptive') mutation [J].

Bridges, BA .

MUTATION RESEARCH-DNA REPAIR, 1998, 408 (01) :1-9

[7] Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase [J].

Chen, L ;

Trujillo, K ;

Sung, P ;

Tomkinson, AE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (34) :26196-26205

[8] Massive gene decay in the leprosy bacillus [J].

Cole, ST ;

Eiglmeier, K ;

Parkhill, J ;

James, KD ;

Thomson, NR ;

Wheeler, PR ;

Honoré, N ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Mungall, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, RM ;

Devlin, K ;

Duthoy, S ;

Feltwell, T ;

Fraser, A ;

Hamlin, N ;

Holroyd, S ;

Hornsby, T ;

Jagels, K ;

Lacroix, C ;

Maclean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Quail, MA ;

Rajandream, MA ;

Rutherford, KM ;

Rutter, S ;

Seeger, K ;

Simon, S ;

Simmonds, M ;

Skelton, J ;

Squares, R ;

Squares, S ;

Stevens, K ;

Taylor, K ;

Whitehead, S ;

Woodward, JR ;

Barrell, BG .

NATURE, 2001, 409 (6823) :1007-1011

[9] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[10] DNA-end-joining: from yeast to man [J].

Critchlow, SE ;

Jackson, SP .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (10) :394-398

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