Synthesis, activity and theoretical study of ABT-418 analogues

被引：8

作者：

Avenoza, A ^{[1
]}

Busto, JH

Cativiela, C

Dordal, A

Frigola, J

Peregrina, JM

机构：

[1] Univ La Rioja, Dept Quim, Grp Sintesis Quim La Rioja, UA,CSIC, Logrono 20006, Spain

[2] Univ Zaragoza, Dept Quim Organ, Inst Ciencia Mat Aragon, CSIC, E-50009 Zaragoza, Spain

[3] Lab Dr Esteve SA, Barcelona 08041, Spain

来源：

TETRAHEDRON | 2002年 / 58卷 / 22期

关键词：

amino acids and derivatives; bicyclic heterocyclic compounds; biologically active compounds; isoxazoles; molecular modeling/mechanics;

D O I：

10.1016/S0040-4020(02)00388-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report shows the synthesis and biological evaluation of two new conformationally restricted ABT-418 analogues. This restriction is introduced by the incorporation of the 7-azabicyclo[2.2.1]heptane skeleton. Furthermore, we report here a high-level quantum mechanical study of their conformations in the gas phase. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：4505 / 4511

页数：7

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